报告题目：聚多肽：从蛋白质到聚合物合成的新方法
报 告 人：Prof. Colin Bonduelle（法国波尔多大学）
报告时间：2025年7月17日（星期四）上午10:00—11:30
报告地址：五山校区科技园2号楼324室
报告邀请人：唐雯
邀请单位：前沿软物质学院
报告摘要：
Proteins are natural building blocks that possess many features still unrivaled by their synthetic counterparts, including chemical diversity, hierarchical structure, specific chemical modification, and programmed system dynamics. Combined with their potential for metabolism in living systems (biodegradation, etc.), these properties make proteins highly attractive for designing the polymers of tomorrow. While significant advances have been achieved in genetic engineering, a major remaining challenge is optimizing large scale protein production (extraction, recombinant protein, etc.). Interestingly, the most economical and efficient route to polypeptides is a chemical approach: the ring-opening polymerization (ROP) of amino acid N-carboxyanhydride (NCA) monomers. Compared to proteins, peptidic polymers are much simpler macromolecules in which amino acids are statistically repeated. However, these polypeptides combine advantageous features of synthetic polymers (solubility, processability, rubber elasticity, etc.) with those of natural proteins (secondary structure, functionality, biocompatibility, etc.). Recent progress in this field has been impressive, and this talk will illustrate: 1) how the secondary structure and of the macromolecular engineering of polypeptide guide the design of advanced materials, 2) how aqueous ROP of NCA monomers can be extended to a PISA process, and 3) how polymerization of NCAs can afford simplified analogues of natural proteins.
个人介绍：
Colin Bonduelle is a research director at CNRS (HDR 2018) and leads research at LCPO, Université de Bordeaux, focusing on bioinspired polymers at the interface of biology and medicine. He completed his PhD in molecular chemistry at the University of Toulouse with Didier Bourissou and was a postdoctoral fellow under the supervision of E. Gillies at Western University in Canada, where he worked on amphiphilic copolymers. He is now an expert in ring-opening polymerization and currently works on the synthesis, characterization, and application of protein-like polymers. His in-depth expertise in N-carboxyanhydride chemistry, along with the new tools he has recently developed in Polymerization-Induced Self-Assembly (PISA), provide excellent platforms for designing polymers for tomorrow’s applications. This work has recently included ring-expansion methodologies to mimic antimicrobial peptides (in collaboration with B. Dupuy at Institut Pasteur) and aqueous ring-opening polymerization processes (water-assisted or ROPISA). He is co-author of more than 60 articles and 9 patents. He was selected for the CNRS Cadre à Haut Potentiel (CHP) class of 2022 and is currently supervising a team of nine PhD students.